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CIHR Skin Research Training Centre
Yabin Cheng


Yabin Cheng (Graduate Student)

Supervisor: Dr. Youwen Zhou (acting)

Term: 2010-02-01~2012-01-31

Project title: The tumor suppressor Fbw7 regulates melanoma cell migration through MAPK-ERK signalling pathway


After obtaining my Master degree in Pharmacology in China I came to Canada to pursue further academic achievement, broader knowledge and international perspective in dermatology research. It’s my great honour to join Department of Dermatology and Skin Science in UBC. We have excellent professors, research fellows and colleagues here in this department. I enjoyed the past three years training in the Dermatology Department and I believe this experience will be very beneficial for my future career.
Now my work focuses on the role of ubiquitin ligase Fbw7 in human melanoma. Fbw7 is responsible for the ubiquitylation and degradation of a set of important proteins in cell cycle progression, proliferation and cell division. I am quite interested in the potential role of Fbw7 in melanoma since not much is known so far. Hopefully my study will be helpful to offer more insights in the molecular mechanism of melanoma and clinical gene targeted therapy.  


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