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CIHR Skin Research Training Centre
Almass-Houd Aguissa Toure

 

Almass-Houd Aguissa Toure (Postdoctoral Fellow)

Supervisor: Dr. Gang Li

Term: 2010-11-01~2011-10-31

Project title: The molecular mechanisms of ING1 in genomic instability, replication stress and cancer

                                                                                                                                                   
 

I did my Master’s and Doctoral degrees at University of Toulouse (France). After my Master’s degree on Noc4p, an essential protein in yeast ribosome biogenesis, it was reported that a mutation in the gene encoding for the ribosomal protein S19 is the source of Diamond-Blackfan anemia (DBA), a rare genetic disease. For my PhD, I decided to work on the link between S19 and this new reported disease. By this work, we demonstrated for the first time the molecular bases of the Diamond-Blackfan anemia, by the same way, the link between the ribosome function and a rare congenital disease. The study represented the complete analytical modeling using archaea, yeast and higher eukaryote species.
Since April 2010, I started a post-PhD research on ING tumor suppressor family proteins. For this work I am focusing on the molecular mechanisms of ING1 in genomic instability, replication stress and cancer. 


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