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CIHR Skin Research Training Centre
Core Mentors: Dr. John Esdaile
John Esdaile, MD, MPH, FRCPC
Scientific Director, Arthritis Research Center of Canada
Adjunct Professor of Medicine and Community Health Sciences, University of Calgary 
Professor of Medicine, Division of Rheumatology, Department of Medicine, University of British Columbia

5591 No. 3 Road, Richmond, BC V6X 2C7
Tel: 604 207-4001
Fax: 604 207-4059
Webstie: http://www.arthritisresearch.ca/complete-projects/49-esdaile.html
Email: jesdaile@arthritisresearch.ca


1969 BSc, McGill University
1971 MD,CM, Medicine, McGill University
1971-1972 Royal Intern, Straight Medicine, Victoria Hospital, Montreal
1972-1973 General Practice, Medicine, Magog, Quebec
1973-1974 Senior. Asst. Resident, Medicine, Montreal General Hospital
1974-1975 Resident, Immunology, Montreal General Hospital
1975-1976 Fellow, Rheumatology, Wellesley Hospital, Toronto
1976-1977 Fellow, Research, Kennedy Institute of Rheumatology, London, England
1986 MPH, Chronic Disease Epidemiology, Yale University

Awards and honors

2005 Distinguished Investigator Award (Canadian Rheumatology Association)
2006 Kirkland Foundation Scholar (US)
2007 Fellow of the Canadian Academy of Health Sciences
2009 University of British Columbia Killam Faculty Research Prize for Science
2009 Vancouver Coastal Health Research Institute Scientific Achievement Award
2009 Consumer Champion Award, Canadian Arthritis Network
2010 Roger Demers Prize, Laurentian Rheumatology Association
2011 IMHA Research Ambassadors Knowledge Translation Award 

Grant Support

Canadian Institutes of Health Research 
Vancouver Foundation       

Research interest

Dr. John Esdaile is an internationally respected rheumatologist who spearheaded the creation of the Arthritis Research Centre of Canada.
As one of five principal investigators, Dr. Esdaile was successful in receiving funding for the Canadian Arthritis Network, a federally funded Networks of Centres of Excellence, providing more than $40 million over ten years for arthritis research. This grant involves more than 150 scientists from across Canada, including many from BC.
Dr. Esdaile’s areas of research interest include rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. His publication of the efficacy of hydroxychloroquine in systemic lupus erythematosus is considered a landmark paper that has altered the treatment of this disease for many patients.
Dr. Esdaile has authored more than 200 publications in refereed journals, as well as more than two dozen books and book chapters.

Current lab members

Research staff:
Aliya Haji (Research Assistant)
Allison Heath (Research Assistant)
Erin Carruthers (Research Assistant)
Jenny Leese (Research Assistant)
Joanna Ye (Research Assistant)
Morgan Barber (Research Assistant)
Lindsay Wall (Research Assistant)
Charlene Yousefi (Research Coordinator)
Daphne Savoy (Orthopaedics Research Coordinator)
Eric Sayre (Research Statistical Analyst)
Helen Prlic (Research Team Coordinator)
Lorna McLean (Orthopaedics Research Coordinator)
Nicole Prestley (Research Coordinator)
Pam Rogers (Research Coordinator)
Sennait Yohannes (Research Coordinator)

Research trainees:
Charles Ratzlaff (Postdoctoral fellow)
Lynne Feehan(PhD)
Behnam Sharif (PhD Candidate)
Mushfiqur Rahman (PhD Candidate)
Nick Bansback (PhD Candidate)
Wei Zhang (PhD Candidate)
Arun Agha (MSc Candidate)
Claire Barber (MSc Candidate)
Lindsay Wall (MSc Candidate)

Selected recent publications

  1. Koehn CL, Esdaile JM. Patient education and self-management of musculoskeletal conditions. Best Pract Res Clin Rheumatol 2008;22:395–405.
  2. Lacaille D, Guh D, Abrahamowicz M, Anis AH, Esdaile JM. Use of non-biologic disease-modifying anti-rheumatic drugs and increased risk of infection in patients with rheumatoid arthritis. Arthritis Rheum 2008;59:1074-1081.
  3. Lacaille D, White MA, Rogers PA, Backman CL, Gignac MA, Esdaile JM. A proof-of-concept study of the “Employment and Arthritis: Making it work:” program. Arthritis Rheum 2008;59:1647-55.
  4. Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: a meta-analysis of observational studies. Arthritis Rheum 2008;59:1690-7.
  5. Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum 2009;60:1372-80.
  6. Sayre EC, Li LC, Kopec JA, Esdaile JM, Bar S, Cibere J. The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis. PLoS One. 2010 May 3;5(5):e10470.
  7. Grindrod KA, Marra CA, Colley L, Cibere J, Tsuyuki RT, Esdaile JM, Gastonguay L, Kopec J. After patients are diagnosed with knee osteoarthritis, what do they do? Arthritis Care Res 2010;62:510-5.
  8. Ratzlaff C, Doerfling P, Steininger G, Koehoorn M, Cibere J, Liang M, Esdaile J, Wilson D, Kopec J. Lifetime trajectory of physical activity according to energy expenditure and joint force. Arthritis Care Res 2010;62:1452-9.
  9. Cibere J, Zhang H, Thorne A, Wong H, Singer J, Kopec JA, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. Association of clinical findings with pre-radiographic and radiographic knee osteoarthritis in a population-based study. Arthritis Care Res 2010;62:1691-8.
  10. Lehman AJ, Pratt DD, Delongis A, Collins JB, Shojania K, Koehler B, Offer R, Esdaile JM. Do spouses know how much fatigue, pain, and physical limitation their partners with rheumatoid arthritis experience? Implications for social support. Arthritis Care Res 2010;63:120-7.
  11. Doerfling P, Kopec JA, Liang MH, Esdaile JM. The effect of cash lottery on response rates to an online health survey among members of the Canadian Association of Retired Persons: a randomized experiment. Can J Public Health 2010;101:251-4.
  12. Ratzlaff C, Steininger G, Doerfling P, Koehoorn M, Cibere J, Liang M, Wilson D, Esdaile J, Kopec J. Influence of lifetime hip joint force on the risk of self-reported hip osteoarthritis: a community-based cohort study. Osteoarthritis Cartilage 2011;19:389-98.
  13. Aviña-Zubieta JA, Choi HK, Abrahamowicz A, Rahman M, Sylvestre MP, Esdaile JM, Lacaille D. Risk of cerebrovascular disease associated with the use of glucocorticoids in patients with incident rheumatoid arthritis. A population-based study. Ann Rheum Dis 2011;70(6):990-5.
  14. Ip S, Sayre EC, Guermazi A, Nicolaou S, Wong H, Thorne A, Singer J, Kopec JA, Esdaile JM, Cibere J. Frequency of bone marrow edema in knee osteoarthritis and association with pain severity: results from a population-based study. J Rheumatol 2011;38(6):1079-85.
  15. Cibere J, Sayre EC, Guermazi A, Nicolaou S, Kopec JA, Esdaile JM, Thorne A, Singer J, Wong H. Natural history of cartilage defects and osteoarthritis progression on magnetic resonance imaging in a population-based cohort with knee pain. Osteoarthritis Cartilage 2011;19(6):683-8.
  16. Li LC, Sayre EC, Kopec J, Esdaile JM, Bar S, Cibere J. Quality of non-pharmacological care for people with osteoarthritis in the community. J Rheumatol 2011;38(10):2230-7.
  17. Crema MD, Guermazi A, Sayre EC, Roemer FW, Wong H, Thorne A, Singer J, Esdaile JM, Marra MD, Kopec JA, Nicolaou S, Cibere J. The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: the MoDEKO study. Osteoarthritis Cartilage 2011;19(12):1429-32.
  18. Marra CA, Lynd LD, Colley L, Harvard SS, Lacaille D, Schwenger E, Anis AH, Esdaile JM. The risk of gastrointestinal events in rheumatoid arthritis patients after the withdrawal of rofecoxib. J Rheumatol 2012;39(5):910-5.
  19. Karp I, Abrahamowicz M, Fortin PR, Pilote L, Neville C, Pineau CA, Esdaile JM. Longitudinal evolution of coronary heart disease risk in systemic lupus erythematosus. J Rheumatol 2012;39(5):968-73.
  20. Lung R, O’Brien J, Grebenyuk J, Forster BB, De Vera M, Kopec J, Ratzlaff C, Garbuz D, Prlic H, Esdaile JM. The prevalence of radiographic femoroacetabular impingement in younger individuals undergoing total hip replacement for osteoarthritis. Clin Rheumatol 2012 Aug;31(8):1239-42.
  21. Wiwatwongwana D, Esdaile JM, White VA, Dolman PJ. Intravenous immunoglobulin (IVIG) for orbital Wegener's granulomatosis. Can J Ophthalmol. 2012 Feb;47(1):82-3.
  22. Marra C, Cibere J, Grubisic M, Grindrod K, Gastonguay L, Thomas J, Embley P, Colley L, Tsuyuki R, Khan K, Esdaile J. Pharmacist initiated intervention trial in osteoarthritis (PhIT-OA): A multidisciplinary intervention for knee osteoarthritis. Arthritis Care Res (Hoboken). 2012 Aug 28. [Epub ahead of print] 

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