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CIHR Skin Research Training Centre
Affiliated Mentors: Dr. David Granville
David Granville, PhD
Associate Professor/Canada Research Chair/MSFHR Scholar
UBC James Hogg Research Centre, Institute for Heart + Lung Health
St. Paul’s Hospital, University of British Columbia

Rm 166 -1081 Burrard Street, Vancouver, B.C. V6Z 1Y6
Tel: 604-806-9267
Fax: 604-806-9274
Website: http://www.hli.ubc.ca/research/PIs/Granville.html
Email: david.granville@hli.ubc.ca
                                                                                                                    

Education

1994 BSc, Simon Fraser University, Biological Sciences
2001 PhD, The University of British Columbia, Pathology and Laboratory Medicine
2003 PDF, The Scripps Research Institute, Molecular and Experimental Medicine

Awards and honors

2003 Michael Smith Foundation for Health Research Scholar Award
2005 Canada Top 40 Under 40™ award by Caldwell and Partners
2006 UBC Outstanding Young Alumnus Award
2007 SFU Academic Alumnus Award
2008 Canadian Association Junior Scientist Award
2010 Business in Vancouver Top Forty Under 40 Award
2007 Louis and Arnold Katz Basic Science Prize

Grant Support

Canadian Institutes of Health Research
BC Transplant Foundation
Genome BC
BC Lung Association
Canadian Foundations for Innovation 

Research interest

• Apoptosis, Proteases, Aging, Atherosclerosis, Extracellular Matrix, Aneurysms, Aortic Dissections, Oxidative stress, Vascular injury mechanisms, skin injury mechanisms
• Aging and Neurodegenerative Disease
• Cardiovascular & Pulmonary
• Dermatology
• Immunology
• Infectious Diseases
• Molecular Pathology
Current Research Activities:
My current research activities are focused on mechanisms of injury, inflammation and repair. Specific areas of interest include:
• Basic roles of the serine protease family, Granzymes, in tissue injury, inflammation and disease
• Mechanisms of age-related tissue degeneration
• Role and regulation of granzymes in wound healing
• Mechanisms of vascular injury in the context of aortic aneurysm, atherosclerosis and allograft vasculopathy
• Mechanisms of age-related skin injury and impaired healing

Current lab members

Dr. Leigh Parkinson (Post-doctoral fellow)
Paul Hiebert (Graduate student)
Alon Hendel (Graduate student)
Lisa Ang (Graduate student)
Hongyan Zhao (Technician)
Ivy Hsu (Graduate student)
Shunsuke Takenaka (Research Scientist)
Andrea Brown (Technician)
 

Selected recent publications

  1. Hiebert PR, Granville DJ. Granzyme B in injury, inflammation, and repair. Trends Mol Med. 2012 Oct 22. pii: S1471-4914(12)00186-4. doi: 10.1016/j.molmed.2012.09.009.
  2. McElhaney JE, Zhou X, Talbot K, Soethout E, Bleackley RC, Granville DJ, Pawelec G. The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines. Vaccine. 2012; 30(12):2060-2067.
  3. Boivin WA, Shackleford M, Vanden Hoek A, Zhao H, Hackett TL, Knight DA, Granville DJ. Granzyme B cleaves Decorin, Biglycan and soluble Betaglycan and releases active transforming growth factor-β. PLoS One. 2012;7(3):e33163.
  4. Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM. Inflammation in myocardial diseases. Circ Res. 2012 Jan 6;110(1):126-44. PMID: 22223210 [PubMed - in process]
  5. L S Ang, W A Boivin, S J Williams, H Zhao, T Abraham, K Carmine-Simmen, B M McManus, R C Bleackley and D J Granville. Serpina3n attenuates granzyme B-mediated decorin cleavage and rupture in a murine model of aortic aneurysm. Cell Death Dis. 2011 Oct 13;2:e215. PMID: 21993391.
  6. Cooper DM, Petchkovsky DV, Hackett TL, Knight DA, Granville DJ. Granzyme K activates protease activated receptor-1. 2011. PLoS One (In press)
  7. Hiebert PR, Abraham Y, Pazooki S, Boivin WA, Zhao H, Granville DJ. Granzyme B Contributes to Extracellular Matrix Remodelling and Skin Aging in Apolipoprotein E Knockout Mice. Exp. Gerontol. 2011, 46:489-499.
  8. Chamberlain CM, Ang LS, Boivin WA, Williams SJ, Zhao H, Folkesson M, Swedenborg J, Allard MF, McManus BM, Granville DJ. Perforin-independent extracellular Granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol. 2010, 176(2):1038-49.
  9. Granville, DJ. Granzymes in disease: bench to bedside. Cell Death Differ. 2010, 17:565-566.
  10. Hendel A, Boivin P, Hiebert A, Williams S, Granville DJ. Granzymes in age-related cardiovascular and pulmonary diseases. Cell Death Differ. 2010, 17: 596-606. 2010
  11. Boivin WA, Cooper D, Hiebert P, Granville DJ. Intracellular versus extracellular granzyme B in immunity and disease: Challenging the dogma. Lab Invest. 2009; 89: 1195-1220. *Figure featured on Cover.
  12. Hunter AL, Kerjner A, Mueller KJ, McManus BM, Granville DJ. Cytochrome p450 2C enzymes contribute to peritransplant ischemic injury and cardiac allograft vasculopathy. Am J Transplant. 2008 Aug;8(8):1631-8.
  13. Rahmani M, Cruz RP, Granville DJ, McManus BM. Allograft vasculopathy versus atherosclerosis. Circ Res. 2006 Oct 13;99(8):801-15. *Co-corresponding Authors.
  14. Choy JC, Cruz RP, Kerjner A, Geisbrecht J, Sawchuk T, Fraser SA, Hudig D, Bleackley RC, Jirik FR, McManus BM, Granville DJ. Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. Am J Transplant. 2005 Mar;5(3):494-499.
  15. Choy JC, Hung VH, Hunter AL, Cheung PK, Motyka B, Goping IS, Sawchuk T, Bleackley RC, Podor TJ, McManus BM, Granville DJ. Granzyme B induces smooth muscle cell apoptosis in the absence of perforin: involvement of extracellular matrix degradation. Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2245-50.
  16. Granville DJ, Tashakkor B, Takeuchi C, Gustafsson AB, Huang C, Sayen MR, Wentworth P Jr, Yeager M, Gottlieb RA. Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1321-6. 

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